STEP 3: Determine the PEP Recommendation
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EC
1 1 2 2 3 |
HIV SC
1 2 2 2 1 or 2 |
PEP Recommendation
PEP may not be warranted. Exposure type does not pose a known risk for HIV transmission. Whether the risk for drug toxicity outweighs the benefit of PEP should Ire decided by the exposed HCW and treating clinician. Consider basic regimen.*Exposure type poses a negligible risk for HIV transmission. A high HIV titer in the source may justify consideration of PEP. Whether the risk for drug toxicity outweighs the benefit of PEP should be decided by the exposed HCW and treating clinician. Recommend basic regimen. Most HIV exposures are in this category; no Increased risk for HIV transmission has been observed but use of PEP is appropriate. Recommend expanded regimen.† Exposure type represents an increased HIV transmission risk. Recommend expanded regimen. Exposure type represents an increased HIV transmission risk. |
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► Unknown ◄
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If the source or, in the case of on unknown source, the setting where the exposure occurred suggests a possible risk for HIV exposure and the EC is 2 or 3, consider PEP basic regimen.
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*
† |
Basic regimen is four weeks of zidovudine, 600 mg per day in two or three divided doses, and lamivudine, 150 mg twice daily.
Expanded regimen is the basic regimen plus either indinavir, 800 mg every 8 hours, or nalfinavir, 750 mg three times a day. |
