Recommendations for the Selection of Drugs for PEP
The selection of a drug regimen for HIV PEP must strive to balance the risk for infection against the potential toxicity of the agent(s) used. Because PEP is potentially toxic, its use is not justified for exposures that pose a negligible risk for transmission (Figure 1). Also, there is insufficient evidence to recommend a highly active regimen for all HIV exposures. Therefore, two regimens for PEP are provided (Table 1): a "basic" two-drug regimen that should be appropriate for most HIV exposures and an "expanded" three-drug regimen that should be used for exposures that pose an increased risk for transmission (Figure 1) or where resistance to one or more antiretroviral agents is known or suspected. When possible, the regimens should be implemented in consultation with persons having expertise in antiretroviral treatment and HIV transmission.