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TABLE 1. Basic and Expanded Postexposure Prophylaxis Regimens


Regimen
Category

Application

Drug Regimen


Basic
Occupational HIV exposures for which there is a recognized transmission risk (Figure 1).
4 weeks (28 days) of both zidovudine 600 mg every day in divided doses (i.e., 300 mg twice a day, 200 mg three times a day, or 100 mg every 4 hours) and lamivudine 150 mg twice a day.
Expanded
Occupational HIV exposures that pose an increased risk for transmission (e.g., larger volume of blood and/or higher virus titer in blood) (Figure 1).
Basic regimen plus either indinavir 800 mg every 6 hours or nelfinavir 750 mg three times a day.*

*
Indinavir should be taken on an empty stomach (i.e., without food or with a light meal) and with increased fluid consumption (i.e., drinking six 8 oz. glasses of water throughout the day); nelfinavir should be taken with meals.
◄ Selection of PEP Drugs
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