TABLE 1. Basic and Expanded Postexposure Prophylaxis Regimens
|
Regimen
Category |
Application |
Drug Regimen |
|
Basic
|
Occupational HIV exposures for which there is a recognized transmission risk (Figure 1).
|
4 weeks (28 days) of both zidovudine 600 mg every day in divided doses (i.e., 300 mg twice a day, 200 mg three times a day, or 100 mg every 4 hours) and lamivudine 150 mg twice a day.
|
|
Expanded
|
Occupational HIV exposures that pose an increased risk for transmission (e.g., larger volume of blood and/or higher virus titer in blood) (Figure 1).
|
Basic regimen plus either indinavir 800 mg every 6 hours or nelfinavir 750 mg three times a day.*
|
|
*
|
Indinavir should be taken on an empty stomach (i.e., without food or with a light meal) and with increased fluid consumption (i.e., drinking six 8 oz. glasses of water throughout the day); nelfinavir should be taken with meals.
|
